W329118
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W329118
Aldrich
4-Hydroxybutanoic acid lactone
≥98%, FCC, Kosher
| Synonym: | γ-Butyrolactone, γ-Hydroxybutyric acid lactone, 4-Hydroxybutyric acid lactone, GBL |
| CAS Number: | 96-48-0 |
| Linear Formula: | C4H6O2 |
| Molecular Weight: | 86.09 |
| FEMA Number: | 3291 |
| Beilstein Registry Number: | 105248 |
| EC Number: | 202-509-5 |
| Council of Europe no.: | 615 |
| MDL number: | MFCD00005386 |
| PubChem Substance ID: | 24901615 |
| Flavis number: | 10.006 |
Description
| Biochem/physiol Actions | Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release. |
| F&F Certificates | US Natural Certificate |
| Continuing Guarantee Statement | |
| GMO Statement | |
| Allergen Statement | |
| EU Natural Certificate | |
| HALAL Statement |
Properties
| grade | FCC |
| Kosher | |
| NI | |
| vapor density | 3 (vs air) |
| vapor pressure | 1.5 mmHg ( 20 °C) |
| assay | ≥98% |
| autoignition temp. | 851 °F |
| expl. lim. | 16 % |
| refractive index | n |
| bp | 204-205 °C(lit.) |
| mp | −45 °C(lit.) |
| density | 1.12 g/mL at 25 °C(lit.) |
| Organoleptic | caramel |
Safety
References
| reference | Walters, J.R., and Roth, R.H., Dopaminergic neurons: drup-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow. J. Pharmacol. Exp. Ther. 191, 82-91, (1974) |
| Ohkawa, S., et al., Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. J. Med. Chem. 34, 267-276, (1991) | |
| Koeltzow, T.E., Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J. Neurosci. 18, 2231, (1998) | |
| Merck | Merck 13,1596 |
| Beilstein | Beil. 17,V,9,7 |
| Fieser | Fieser 1,101 |
| Aldrich MSDS 1, 337:A / Arctander, 552 / Corp MSDS 1 (1), 656:A / FT-IR 2 (1), 1174:A / FT-IR 1 (1), 697:D / FT-NMR 1 (1), 1127:A / Fenaroli, 99 / IR-Spectra (2), 360:H / IR-Spectra (3), 407:F / NMR-Reference 2 (1), 590:C / RegBook 52 (1), 803:J / RegBook 1 (1), 803:J / Sax 6, 549 / Sigma FT-IR 1 (2), 623:A / Structure Index 1, 125:D:6 / Vapor Phase 3, 749:A |
